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Utility of video capsule endoscopy for longitudinal monitoring of Crohn's disease activity in the small bowel: a prospective study

15 Fev. 2019 |

Melmed GY1, Dubinsky MC2, Rubin DT3, Fleisher M4, Pasha SF5, Sakuraba A3, Tiongco F6, Shafran I7, Fernandez-Urien I8, Rosa B9, Papageorgiou NP10, Leighton JA5.

1F Widjaja Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, California, USA.

2Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Mount Sinai Hospital, New York, New York, USA.

3Inflammatory Bowel Disease Center, The University of Chicago Medicine, Chicago, Illinois, USA.

4Division of Hepatology and Gastroenterology, Borland-Groover Clinic, Jacksonville, Florida, USA.

5Division of Gastroenterology and Hepatology, Mayo Clinic Arizona, Scottsdale, Arizona, USA.

6Clinical Research Division, Gastroenterology Associates of Tidewater, Chesapeake, Virginia, USA.

7Shafran Gastroenterology Research Center, Winter Park, Florida, USA.

8Department of Gastroenterology, Hospital de Navarra, Navarra, Spain.

9Department of Gastroenterology, Hospital da Senhora da Oliveira, Guimarães, Portugal.

10Department of Gastroenterology, American Medical Center, Nicosia, Cyprus.

ABSTRACT

Background and aims:

This prospective, multicenter study evaluated small-bowel capsule endoscopy (CE) for the longitudinal assessment of mucosal inflammation in subjects with Crohn's disease (CD).

Methods:

Subjects with known CD underwent clinical evaluation with ileocolonoscopy and CE at baseline and 6-month follow-up. Small-bowel patency was confirmed before CE at both time points. The Simple Endoscopic Score for CD (SES-CD) was used for ileocolonoscopy, and the Lewis score and the CE CD Endoscopic Index of Severity (CECDEIS) were used for CE. Clinical scoring indices included the Physician Global Assessment (PGA), CD Activity Index (CDAI), and Harvey-Bradshaw Index (HBI). Laboratory markers including C-reactive protein, fecal calprotectin, and erythrocyte sedimentation rate were collected at baseline and follow-up. Correlation between endoscopic scores and clinical parameters were measured using Spearman tests.

Results:

A total of 74 subjects were enrolled, of whom 53 (72%) completed endoscopic procedures at baseline and 6-month follow-up. The SES-CD ileocolonoscopy score correlated with the Lewis score (P < .001, ρ = .59) and CECDEIS capsule score (P = .002, ρ = .48). None of the 3 endoscopic scores correlated with PGA, CDAI, HBI, C-reactive protein, erythrocyte sedimentation rate, or fecal calprotectin. Approximately 85% of subjects had proximal small-bowel inflammation identified on CE. There were no CE-related adverse events.

Conclusions:

There was high correlation between CE and ileocolonoscopy scores for the assessment of mucosal disease activity over time; however, there were no correlations between endoscopic scores and clinical parameters. The use of serial CE for the assessment of small-bowel CD is feasible and valid. (Clinical trial registration number: NCT01942720.).

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