Monteiro S1, Cúrdia Gonçalves T1, Boal Carvalho P1, Moreira MJ1, Cotter J1.
1Department of Gastroenterology, Hospital da Senhora da Oliveira-Guimarães, Portugal; University of Minho School of Medicine, Braga, Guimarães, Portugal; Associate Laboratory ICVS, 3B's, Braga, Guimarães, Portugal. Este endereço de email está protegido contra piratas. Necessita ativar o JavaScript para o visualizar.
ABSTRACT
Background/Aims
Identifying predictors of endoscopic recurrence (ER) has become very important to guide the decision of postoperative strategy. This study aimed to determine the rate of endoscopic recurrence until 12 months after ileocolic resection for Crohn disease (CD) in a cohort and identify its possible predictors.
Materials and Methods
We conducted a retrospective single-center study that included patients with CD who underwent ileocolic resection between 2003 and 2014. ER was defined according to the Rutgeerts’ score, defined as i2, i3, or i4 at ileocolonoscopy that was performed 6-12 months after surgery. The patients were classified into two groups according to the Rutgeerts ́ score: non-ER (Rutgeerts i0/i1) and ER (Rutgeerts ≥i2). Multivariate logistic regression analysis was performed, includingsignificant variables on univariable analysis, to identify ER predictors.
Results
Forty-two patients were included. The mean period of the first postoperative colonoscopy was 9 months, and ER was observed in 25 patients (59.5%). The perianal disease and shorter duration of CD were the only ER pre-dictors (p=0.024; OR, 8.36; 95% CI, 1.329-52.642 and p=0.039; OR, 0.965; 95% CI, 0.933-0.998, respectively).
Conclusion
Endoscopic recurrence affects almost two-thirds of patients with CD after ileocolic resection, with perianal involvement and a shorter duration of disease being significant risk factors. These factors may indicate a more aggressive disease associated with rapid progression and support the need of intensive early treatment to improve patients’ outcomes.
